Analysis of the Mitochondrial 4977 Bp Deletion in Patients with Hepatocellular Carcinoma

Abstract

Mutations in the mitochondrial (mt) genome that result in mt dysfunction, have long been proposed to play important roles in the pathogenesis of hepatocellular carcinoma (HCC). Among these, the common mtDNA 4977 bp deletion is one of the most frequent mutations observed in various cancers. To understand the relationship between the mtDNA 4977 bp deletion… (More)
DOI: 10.1515/bjmg-2017-0006

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