Analysis of the Membrane Proteome of Ciprofloxacin-Resistant Macrophages by Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)

@inproceedings{Caceres2013AnalysisOT,
  title={Analysis of the Membrane Proteome of Ciprofloxacin-Resistant Macrophages by Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)},
  author={Nancy E. Caceres and Maarten Aerts and B{\'e}atrice Marquez and Marie-Paule Mingeot-Leclercq and Paul M Tulkens and Bart Devreese and Françoise Van Bambeke},
  booktitle={PloS one},
  year={2013}
}
Overexpression of multidrug transporters is a well-established mechanism of resistance to chemotherapy, but other changes may be co-selected upon exposure to drugs that contribute to resistance. Using a model of J774 macrophages made resistant to the fluoroquinolone antibiotic ciprofloxacin and comparing it with the wild-type parent cell line, we performed a quantitative proteomic analysis using the stable isotope labeling with amino acids in cell culture technology coupled with liquid… CONTINUE READING

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