Analysis of the IFN-gamma-signaling pathway in macrophages at different stages of maturation.

@article{Lucas1998AnalysisOT,
  title={Analysis of the IFN-gamma-signaling pathway in macrophages at different stages of maturation.},
  author={D. Lucas and Mary A. Lokuta and Mary McDowell and Joyce E. S. Doan and Donna M. Paulnock},
  journal={Journal of immunology},
  year={1998},
  volume={160 9},
  pages={4337-42}
}
We previously demonstrated that the macrophage cell lines RAW 264.7 and WEHI-3 exhibit distinct patterns of gene expression in response to IFN-gamma. This difference is controlled at the transcriptional level and results from a specific inability of the less mature WEHI-3 cells to utilize either the IFN-stimulated response element or the gamma-activated sequence DNA regulatory element in response to stimulation with IFN-gamma, while other aspects of IFN-gamma gene induction remain intact. In… CONTINUE READING
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