Analysis of the H19ICR insulator.

  title={Analysis of the H19ICR insulator.},
  author={Young Soo Yoon and Sangkyun Jeong and Qi Rong and Kye-yoon Park and Jonathan H Chung and Karl E. Pfeifer},
  journal={Molecular and cellular biology},
  volume={27 9},
Transcriptional insulators are specialized cis-acting elements that protect promoters from inappropriate activation by distal enhancers. The H19 imprinting control region (ICR) functions as a CTCF-dependent, methylation-sensitive transcriptional insulator. We analyzed several insertional mutations and demonstrate that the ICR can function as a methylation-regulated maternal chromosome-specific insulator in novel chromosomal contexts. We used chromosome conformation capture and chromatin… CONTINUE READING