Analysis of the Foxp3/scurfin gene in Crohn's disease.

  title={Analysis of the Foxp3/scurfin gene in Crohn's disease.},
  author={Ogyi Park and Irina B Grishina and Patrick S K Leung and M Eric Gershwin and Thomas Prindiville},
  journal={Annals of the New York Academy of Sciences},
Crohn's disease (CD) is a chronic inflammatory bowel disease typified by transmural inflammation affecting any part of the gastrointestinal tract. CD4(+)CD25(+) regulatory T cells (T(reg) cells) play important roles in intestinal homeostasis. Adoptive transfer of regulatory T cells into mice with chronic colitis prevented inflammation and reappearance of normal intestinal architecture. The Foxp3 gene encodes a protein that is a member of the forkhead/winged-helix family of transcriptional… CONTINUE READING


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