Analysis of the Complete Open Reading Frame of Genotype 2b Hepatitis C Virus in Association with the Response to Peginterferon and Ribavirin Therapy

@inproceedings{Kadokura2011AnalysisOT,
  title={Analysis of the Complete Open Reading Frame of Genotype 2b Hepatitis C Virus in Association with the Response to Peginterferon and Ribavirin Therapy},
  author={Makoto Kadokura and Shinya Maekawa and Ryota Sueki and Mika Miura and Kazuki Komase and Hiroko Shindo and Fumitake Amemiya and Tomoyoshi Uetake and Taisuke Inoue and Minoru Sakamoto and Mina Nakagawa and Naoya Sakamoto and Mamoru Watanabe and Nobuyuki Enomoto},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND AND AIMS Patients infected with genotype 2b hepatitis C virus (HCV) generally can achieve favorable responses to pegylated-interferon plus ribavirin therapy (PEG-IFN/RBV). However, a proportion of patients show poorer responses and the correlation between viral sequence variation and treatment outcome remains unclear. METHODS The pretreatment complete open reading frame (ORF) sequences of genotype 2b HCV determined by direct sequencing were investigated for correlation with the… CONTINUE READING

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