Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population.

@article{Dahl1992AnalysisOT,
  title={Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population.},
  author={M L Dahl and Inger Johansson and M P Palmertz and Magnus Ingelman-Sundberg and Folke Sj{\"o}qvist},
  journal={Clinical pharmacology and therapeutics},
  year={1992},
  volume={51 1},
  pages={12-7}
}
The molecular basis of polymorphic debrisoquin hydroxylation was studied in 223 Swedish white subjects, 187 extensive metabolizers and 36 poor metabolizers phenotyped with debrisoquin and desipramine. Restriction fragment length polymorphism (RFLP) analysis of the CYP2D6 gene revealed that 52% of unrelated poor metabolizers were homozygous for Xba I 29 kb fragment, and only 8% had two mutant alleles detected with RFLP. Allele-specific polymerase chain reaction (PCR)-based DNA amplification… CONTINUE READING

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