Analysis of the CC chemokine receptor 5 (CCR5) delta-32 polymorphism in inflammatory bowel disease

@article{Rector2001AnalysisOT,
  title={Analysis of the CC chemokine receptor 5 (CCR5) delta-32 polymorphism in inflammatory bowel disease},
  author={Annabel Rector and S{\'e}verine Vermeire and Inge Thoelen and Els Keyaerts and Frank Struyf and Robert F M H Vlietinck and P. R. Rutgeerts and Marc Van Ranst},
  journal={Human Genetics},
  year={2001},
  volume={108},
  pages={190-193}
}
The inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC) are complex multifactorial traits involving both environmental and genetic factors. Recent studies have shown the important role of pro-inflammatory cytokines and chemokines, including RANTES, in IBD. RANTES is the natural ligand for the CC-chemokine receptor 5 (CCR5). The chromosomal location of the CCR5 gene on 3p21 coincides with an IBD-susceptibility locus identified by genome-wide scanning. A 32-bp… CONTINUE READING
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