Analysis of the Actinobacillus pleuropneumoniae ArcA regulon identifies fumarate reductase as a determinant of virulence.

@article{Buettner2008AnalysisOT,
  title={Analysis of the Actinobacillus pleuropneumoniae ArcA regulon identifies fumarate reductase as a determinant of virulence.},
  author={Falk F R Buettner and Ibrahim M Bendallah and Janine T Boss{\'e} and Karla Dreckmann and John H E Nash and Paul R Langford and Gerald Gerlach},
  journal={Infection and immunity},
  year={2008},
  volume={76 6},
  pages={2284-95}
}
The ability of the bacterial pathogen Actinobacillus pleuropneumoniae to grow anaerobically allows the bacterium to persist in the lung. The ArcAB two-component system is crucial for metabolic adaptation in response to anaerobic conditions, and we recently showed that an A. pleuropneumoniae arcA mutant had reduced virulence compared to the wild type (F. F. Buettner, A. Maas, and G.-F. Gerlach, Vet. Microbiol. 127:106-115, 2008). In order to understand the attenuated phenotype, we investigated… CONTINUE READING
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