Analysis of the 5HT-2A T102C receptor polymorphism and psychotic symptoms in Alzheimer's disease.

@article{Craig2007AnalysisOT,
  title={Analysis of the 5HT-2A T102C receptor polymorphism and psychotic symptoms in Alzheimer's disease.},
  author={David Craig and Caroline E. Donnelly and Dominic J. Hart and Robyn Carson and Anthony Peter Passmore},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2007},
  volume={144B 1},
  pages={
          126-8
        }
}
Although the aetiology of psychotic symptoms in Alzheimer's disease (AD) is multi-factorial, alterations in serotonergic neurotransmission are often implicated. Polymorphisms of the serotonin receptor 5HT-2A are associated with hallucinatory symptoms and delusions in demented and non-demented cohorts. This study examined the role of the 5HT-2A T102C polymorphism in influencing psychotic symptoms in a large Northern Ireland AD population (n = 406, mean MMSE 13/30). Forty-eight percent of… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Behavioural genetics of Alzheimer's disease: a comprehensive review

  • Archives of medical science : AMS
  • 2011
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Genetics of psychosis of Alzheimer disease.

  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND