Analysis of the 5' region of the canine PAX3 gene and exclusion as a candidate for Dalmatian deafness.

@article{Brenig2003AnalysisOT,
  title={Analysis of the 5' region of the canine PAX3 gene and exclusion as a candidate for Dalmatian deafness.},
  author={Bertram Brenig and Ina Pfeiffer and Andr{\'e} Jaggy and Ietje Kathmann and M Balzari and Claude Gaillard and Gaudenz Dolf},
  journal={Animal genetics},
  year={2003},
  volume={34 1},
  pages={47-50}
}
The causative mutation in a gene related to hearing loss in Dalmatians has been elusive. Because of its role in melanocyte migration and differentiation as integral component of the inner ear, we hypothesized that the canine PAX3 (paired box homeotic gene 3) gene could be a candidate for Dalmatian deafness. Therefore, we isolated the canine PAX3 gene and searched for causative mutations within the coding region of important regulatory domains of PAX3. However, no mutations were identified when… CONTINUE READING

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