Analysis of the 3'-variable region of the cagA gene from Helicobacter pylori strains infecting patients at New York City hospitals.

@article{Ogorodnik2013AnalysisOT,
  title={Analysis of the 3'-variable region of the cagA gene from Helicobacter pylori strains infecting patients at New York City hospitals.},
  author={Evgeny Ogorodnik and Robert D Raffaniello},
  journal={Microbial pathogenesis},
  year={2013},
  volume={56},
  pages={29-34}
}
Helicobacter pylori infects the gastric mucosa in humans and is a causative agent for peptic ulcer disease (PUD) and gastric cancer (GC). CagA is produced by H. pylori and is associated with more severe outcomes. cagA genes vary at the 3'-region with respect to phosphorylation motifs (EPIYA-A, -B, -C, or -D) and CagA multimerization motifs (CM). This variability may be associated with the clinical outcomes. We examined the variable region of cagA genes expressed in H. pylori-infected patients… CONTINUE READING

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