Corpus ID: 23994642

Analysis of the 2-deoxy-D-glucose-induced vagal stimulation of gastric secretion and gastrin release in dogs using methionine-enkephalin, morphine and naloxone.

@article{Anderson1982AnalysisOT,
  title={Analysis of the 2-deoxy-D-glucose-induced vagal stimulation of gastric secretion and gastrin release in dogs using methionine-enkephalin, morphine and naloxone.},
  author={W. Anderson and E. Molina and J. Rentz and B. Hirschowitz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1982},
  volume={222 3},
  pages={
          617-22
        }
}

W. Anderson, E. Molina, +1 author B. Hirschowitz

Published 1982

Chemistry, Medicine

The Journal of pharmacology and experimental therapeutics

Gastric acid and pepsin secreted in 3 hr and antral gastrin released in response to vagal excitation induced by 2-deoxy-D-glucose (2DG), 625 mumol/kg i.v., were studied in six conscious trained gastric fistula dogs. During a 2-hr infusion, Met-enkephalin (96 nmol/kg/hr; delta receptor) reduced the 2DG response by 50%; when the enkephalin was stopped there was a rapid rebound to peak values. Met-enkephalin also blocked the release of gastrin in the first 15 min. By itself, Met-enkephalin did not… CONTINUE READING

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