Corpus ID: 23994642

Analysis of the 2-deoxy-D-glucose-induced vagal stimulation of gastric secretion and gastrin release in dogs using methionine-enkephalin, morphine and naloxone.

@article{Anderson1982AnalysisOT,
  title={Analysis of the 2-deoxy-D-glucose-induced vagal stimulation of gastric secretion and gastrin release in dogs using methionine-enkephalin, morphine and naloxone.},
  author={W. Anderson and E. Molina and J. Rentz and B. Hirschowitz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1982},
  volume={222 3},
  pages={
          617-22
        }
}
  • W. Anderson, E. Molina, +1 author B. Hirschowitz
  • Published 1982
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • Gastric acid and pepsin secreted in 3 hr and antral gastrin released in response to vagal excitation induced by 2-deoxy-D-glucose (2DG), 625 mumol/kg i.v., were studied in six conscious trained gastric fistula dogs. During a 2-hr infusion, Met-enkephalin (96 nmol/kg/hr; delta receptor) reduced the 2DG response by 50%; when the enkephalin was stopped there was a rapid rebound to peak values. Met-enkephalin also blocked the release of gastrin in the first 15 min. By itself, Met-enkephalin did not… CONTINUE READING
    13 Citations
    Morphine reduces vagal-stimulated gastric acid secretion through a central action.
    • 6