Analysis of the 1 . 1Mb Human a / d T-Cell Receptor Locus with Bacterial Artificial Chromosome Clones

@inproceedings{Boysen1997AnalysisOT,
  title={Analysis of the 1 . 1Mb Human a / d T-Cell Receptor Locus with Bacterial Artificial Chromosome Clones},
  author={Cecilie Boysen and Melvin I. Simon and Leroy Hood},
  year={1997}
}
Bacterial artificial chromosome (BAC) clones are effective mapping and sequencing reagents. The 1.1-Mb a/d T-cell receptor locus of humans was mapped and partially sequenced with BAC clones. Seventeen BAC clones covered the 1.1-Mb a/d locus, with the exception of one small gap that was expected from the coverage that a 3.7-fold BAC library is likely to provide. The end sequences of the BAC inserts could be obtained directly from the BAC DNA by sequencing with the chain terminator chemistry… CONTINUE READING

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