Analysis of the (CAG)n repeat at the IT15 locus in a population from Calabria (southern Italy).

@article{Leone1997AnalysisOT,
  title={Analysis of the (CAG)n repeat at the IT15 locus in a population from Calabria (southern Italy).},
  author={Olga Leone and Maria Muglia and Anna Lia Gabriele and Grazzia Annesi and Francesca Luisa Conforti and E Imbrogno and L Imbrogno and Carlo Brancati},
  journal={Human biology},
  year={1997},
  volume={69 5},
  pages={653-62}
}
The defect causing Huntington's disease (HD) has recently been discovered as an expanded CAG trinucleotide repeat located at the 5' end of the IT15 gene. This discovery allows the molecular diagnosis of HD by measuring the CAG repeat length. The normal and pathological repeat ranges in a population need to be established before a diagnostic test for HD can… CONTINUE READING