Analysis of tetanus toxin peptide/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma.

@article{Blank1993AnalysisOT,
  title={Analysis of tetanus toxin peptide/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma.},
  author={Ulrich Blank and B Boitel and D M{\`e}ge and Myriam Ermonval and Oreste Acuto},
  journal={European journal of immunology},
  year={1993},
  volume={23 12},
  pages={3057-65}
}
We have previously reported that human T cell receptors (TcR) selected in the class II-restricted (HLA-DRB1*1302) response to a tetanus toxin peptide (tt830-843) frequently used the V beta 2 germ-line segment which paired with several V alpha segments and that the putative CDR3 of both alpha and beta chains showed remarkable heterogeneity. To analyze the structural basis for recognition of the tt830-843/DR complex, five of these TcR were reconstituted into a murine T cell hybridoma, 58 alpha… CONTINUE READING
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