Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers

  title={Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers},
  author={Xiaohong R Yang and Jonine D Figueroa and Roni T Falk and Hong Zhang and Ruth M. Pfeiffer and Stephen M. Hewitt and Jolanta Lissowska and Beata Peplonska and Louise A Brinton and Montserrat Garc{\'i}a-Closas and Mark E. Sherman},
  booktitle={Breast Cancer Research},
Involution of terminal duct lobular units (TDLUs), the structures that give rise to most breast cancers, has been associated with reduced breast cancer risk. Data suggest that the etiology and pathogenesis of luminal A and core basal phenotype (CBP) breast cancers differ, but associations with TDLU involution are unknown. Accordingly, we performed a masked microscopic assessment of TDLU involution in benign tissues associated with luminal A and CBP breast cancers diagnosed among women less than… CONTINUE READING


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Gene expression profiles of estrogen receptor-positive and estrogen receptornegative breast cancers are detectable in histologically normal breast epithelium

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