Analysis of temporal shear stress gradients during the onset phase of flow over a backward-facing step.

@article{Haidekker2001AnalysisOT,
  title={Analysis of temporal shear stress gradients during the onset phase of flow over a backward-facing step.},
  author={Mark A. Haidekker and Charles R. White and John A. Frangos},
  journal={Journal of biomechanical engineering},
  year={2001},
  volume={123 5},
  pages={455-63}
}
Endothelial cells in blood vessels are exposed to bloodflow and thus fluid shear stress. In arterial bifurcations and stenoses, disturbed flow causes zones of recirculation and stagnation, which are associated with both spatial and temporal gradients of shear stress. Such gradients have been linked to the generation of atherosclerotic plaques. For in-vitro studies of endothelial cell responses, the sudden-expansion flow chamber has been widely used and described. A two-dimensional numerical… CONTINUE READING