Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites

@article{Hamik1990AnalysisOT,
  title={Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites},
  author={Anne Hamik and Donna Oksenberg and Christine T. Fischette and Stephen J. Peroutka},
  journal={Biological Psychiatry},
  year={1990},
  volume={28},
  pages={99-109}
}
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95 Citations
Highly Influential Citations
5
Background Citations
29
Methods Citations
3

95 Citations

Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine—II. Effects of acute administration of 1-PP and long-term adminstration of tandospirone on noradrenergic neurotransmission

Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT1A receptors in the rat medial frontal cortex

Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine—I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission

Characterization of 5-hydroxytryptamine1A properties of flesinoxan: In Vivo electrophysiology and hypothermia study

In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response

Despite the significant effect on growth hormone and body temperature, a clinical dose of tandospirone had a negligible effect on [11C]WAY 100635 binding, which indicates that the agonist produces a pharmacological effect without measurable occupancy, and a new index other than occupancy will be required for the in vivo evaluation of agonists.

Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor.

Tandospirone could be a therapeutic candidate for impulsivity-related disorders and may be due to the antagonistic action of the 5-HT1A receptor.

Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPγS binding

The agonist properties of trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP), at 5-HT1A receptors are elucidated by means of the guanosine-5′-O-(3-[ 35S]thio)-triphosphate ([35S]GTPγS) binding assay.

The activity of the serotonergic 5-HT1A receptor is modulated by voltage and sodium levels

The effects of azapirones on serotonin1A neurons of the dorsal raphe.

Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo

The results are the first evidence that systemic 5-HT1A receptor agonist administration produces a rapid increase in p-ERK levels in vivo, providing further insight into the signaling mechanisms of the 5- HT1A receptors.
...

References

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