Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites
@article{Hamik1990AnalysisOT, title={Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites}, author={Anne Hamik and Donna Oksenberg and Christine T. Fischette and Stephen J. Peroutka}, journal={Biological Psychiatry}, year={1990}, volume={28}, pages={99-109} }
95 Citations
Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine—II. Effects of acute administration of 1-PP and long-term adminstration of tandospirone on noradrenergic neurotransmission
- Biology, MedicineNeuropharmacology
- 1991
Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT1A receptors in the rat medial frontal cortex
- Biology, PsychologyNeurochemistry International
- 2002
Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine—I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission
- BiologyNeuropharmacology
- 1991
Characterization of 5-hydroxytryptamine1A properties of flesinoxan: In Vivo electrophysiology and hypothermia study
- BiologyNeuropharmacology
- 1995
In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response
- Biology, MedicinePsychopharmacology
- 2002
Despite the significant effect on growth hormone and body temperature, a clinical dose of tandospirone had a negligible effect on [11C]WAY 100635 binding, which indicates that the agonist produces a pharmacological effect without measurable occupancy, and a new index other than occupancy will be required for the in vivo evaluation of agonists.
Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor.
- Biology, PsychologyJournal of pharmacological sciences
- 2013
Tandospirone could be a therapeutic candidate for impulsivity-related disorders and may be due to the antagonistic action of the 5-HT1A receptor.
Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPγS binding
- Biology, PsychologyJournal of psychopharmacology
- 2005
The agonist properties of trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP), at 5-HT1A receptors are elucidated by means of the guanosine-5′-O-(3-[ 35S]thio)-triphosphate ([35S]GTPγS) binding assay.
The activity of the serotonergic 5-HT1A receptor is modulated by voltage and sodium levels
- BiologyThe Journal of biological chemistry
- 2022
The effects of azapirones on serotonin1A neurons of the dorsal raphe.
- Biology, ChemistryGeneral pharmacology
- 1994
Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo
- Biology, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 2004
The results are the first evidence that systemic 5-HT1A receptor agonist administration produces a rapid increase in p-ERK levels in vivo, providing further insight into the signaling mechanisms of the 5- HT1A receptors.
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