Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites

@article{Hamik1990AnalysisOT,
  title={Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites},
  author={Anne Hamik and Donna Oksenberg and Christine T. Fischette and Stephen J. Peroutka},
  journal={Biological Psychiatry},
  year={1990},
  volume={28},
  pages={99-109}
}

Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats

Findings suggest that behavioural changes induced by tandospirone are not fully blocked by 5-HT1A antagonists and that tandosphereirone (5 mg/kg) potentiates the effect of MK-801, and point to an interaction between NMDA and 5- HT1A receptors.

In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response

Despite the significant effect on growth hormone and body temperature, a clinical dose of tandospirone had a negligible effect on [11C]WAY 100635 binding, which indicates that the agonist produces a pharmacological effect without measurable occupancy, and a new index other than occupancy will be required for the in vivo evaluation of agonists.

Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor.

Tandospirone could be a therapeutic candidate for impulsivity-related disorders and may be due to the antagonistic action of the 5-HT1A receptor.

Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPγS binding

The agonist properties of trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP), at 5-HT1A receptors are elucidated by means of the guanosine-5′-O-(3-[ 35S]thio)-triphosphate ([35S]GTPγS) binding assay.

The activity of the serotonergic 5-HT1A receptor is modulated by voltage and sodium levels

...

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