Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites.

@article{Hamik1990AnalysisOT,
  title={Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites.},
  author={Anne Hamik and Donna Oksenberg and Christine T. Fischette and Stephen J. Peroutka},
  journal={Biological psychiatry},
  year={1990},
  volume={28 2},
  pages={99-109}
}
The interactions of tandospirone (formerly called SM-3997) with 5-HT and other neurotransmitter receptor binding sites were determined in brain homogenates. Tandospirone is most potent at the 5-HT1A receptor, displaying a Ki value of 27 +/- 5 nM. The agent is approximately two to three orders of magnitude less potent at 5-HT2, 5-HT1C, alpha 1-adrenergic, alpha 2-adrenergic, and dopamine D1 and D2 receptors (Ki values ranging from 1300 to 41000 nM). Tandospirone is essentially inactive at 5-HT1B… CONTINUE READING