Analysis of systemic sulfur metabolism in plants using integrated '-omics' strategies.

@article{Hirai2008AnalysisOS,
  title={Analysis of systemic sulfur metabolism in plants using integrated '-omics' strategies.},
  author={Masami Yokota Hirai and Kazuki Saito},
  journal={Molecular bioSystems},
  year={2008},
  volume={4 10},
  pages={
          967-73
        }
}
Sulfur (S) assimilation by plants plays a key role in the S cycle in nature, and metabolism of the assimilated S provides various compounds that are useful for animals, including humans. It is important to understand the mechanisms involved in systemic S metabolism in order to improve crop agronomy and the production of dietary and nutraceutical plants. Recent advances in '-omic' studies have provided comprehensive insights into S metabolism. These studies may be regarded as important case… 
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References

SHOWING 1-10 OF 34 REFERENCES
Post-genomics approaches for the elucidation of plant adaptive mechanisms to sulphur deficiency.
TLDR
These post-genomics studies that have revealed the network linking several pathways related to jasmonic acid (JA), oxidative stress response, auxin, and flavonoid to S metabolic pathway are summarized.
Systems Rebalancing of Metabolism in Response to Sulfur Deprivation, as Revealed by Metabolome Analysis of Arabidopsis Plants1[w]
TLDR
Mutual influences between sulfur assimilation, nitrogen imbalance, lipid breakdown, purine metabolism, and enhanced photorespiration associated with sulfur-deficiency stress are revealed in this study and may be assembled into a global scheme of metabolic regulation induced by sulfur nutritional stress, which optimizes resources for seed production.
Towards dissecting nutrient metabolism in plants: a systems biology case study on sulphur metabolism.
TLDR
The analysis of the response of the transcriptome and metabolome to sulphur deprivation in the growth medium provides a tool set for the analysis of comparable genomics studies of other nutrients.
Integrating genomics and metabolomics for engineering plant metabolic pathways.
Sulfur Assimilatory Metabolism. The Long and Smelling Road1
Sulfur represents the ninth and least abundant essential macronutrient in plants, preceded by carbon, oxygen, hydrogen, nitrogen, potassium, calcium, magnesium, and phosphorus. The dry matter of…
Omics-based identification of Arabidopsis Myb transcription factors regulating aliphatic glucosinolate biosynthesis
TLDR
Two R2R3-Myb transcription factors are found that positively control the biosynthesis of GSLs in Arabidopsis thaliana by an integrated omics approach and a working model for regulation of GSL production involving these genes, renamed Production of Methionine-Derived Glucosinolate (PMG) 1 and 2 are postulated.
Transcriptome analysis of sulfur depletion in Arabidopsis thaliana: interlacing of biosynthetic pathways provides response specificity.
TLDR
Based on the correlative analysis of gene expression patterns, it is suggested that a complex co-ordination of systematic responses to sulfur depletion is provided via integration of flavonoid, auxin and jasmonate pathway elements.
Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in Arabidopsis thaliana.
  • M. Hirai, Mitsuru Yano, +6 authors Kazuki Saito
  • Environmental Science, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
This is the first report of investigation for gene-to-metabolite networks regulating sulfur and nitrogen nutrition and secondary metabolism in Arabidopsis, with integration of metabolomics and transcriptomics, and specific responses to either sulfur or nitrogen deficiency were observed.
Potential of metabolomics as a functional genomics tool.
Transcriptome Profiling of Sulfur-Responsive Genes in Arabidopsis Reveals Global Effects of Sulfur Nutrition on Multiple Metabolic Pathways1[w]
Sulfate is a macronutrient required for cell growth and development. Arabidopsis has two high-affinity sulfate transporters (SULTR1;1 and SULTR1;2) that represent the sulfate uptake activities at the…
...
1
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3
4
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