Analysis of systemic and pulmonary vascular responses to PACAP and VIP: role of adrenal catecholamines.

@article{Minkes1992AnalysisOS,
  title={Analysis of systemic and pulmonary vascular responses to PACAP and VIP: role of adrenal catecholamines.},
  author={Robert K. Minkes and Thomas J. McMahon and Todd R. Higuera and William J. Murphy and D. H. Coy. E. J. Coy and Philip J. Kadowitz},
  journal={The American journal of physiology},
  year={1992},
  volume={263 6 Pt 2},
  pages={H1659-69}
}
Systemic and pulmonary vascular responses to pituitary adenylate cyclase-activating polypeptide (PACAP), a novel peptide with 68% sequence homology to vasoactive intestinal peptide (VIP), were investigated in the anesthetized cat. Intravenous injections of PACAP in doses of 0.1-3.0 nmol/kg produced decreases in arterial pressure (AP) at low doses and biphasic changes (decreases followed by increases) at higher doses, which were accompanied by increases in central venous pressure (CVP) and… CONTINUE READING
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