Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and B.

@article{Galdiero2006AnalysisOS,
  title={Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and B.},
  author={Stefania Galdiero and Mariateresa Vitiello and Marina D'Isanto and Annarita Falanga and C. Collins and Katia Raieta and Carlo Pedone and Helena Browne and Massimiliano Galdiero},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 5},
  pages={1085-97}
}
Human herpesviruses enter cells by fusion of their own membrane with a cellular membrane through the concerted action of multiple viral proteins and cellular receptors. Two conserved viral glycoproteins, gB and gH, are required for herpes simplex virus type 1 (HSV-1)-mediated membrane fusion, but little is known of how these proteins cooperate during entry. Both glycoproteins were shown to contain heptad repeat (HR) sequences predicted to form alpha-helical coiled coils, and the inhibitory… CONTINUE READING

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