Analysis of substitution rates showed that TLR5 is evolving at different rates among mammalian groups

  title={Analysis of substitution rates showed that TLR5 is evolving at different rates among mammalian groups},
  author={Ana Pinheiro and Ana {\'A}gueda-Pinto and Jos{\'e} Melo‐Ferreira and Fabiana Neves and Joana Abrantes and Pedro Jos{\'e} Esteves},
  journal={BMC Evolutionary Biology},
BackgroundToll-like receptors (TLRs) are the most widely studied innate immunity receptors responsible for recognition of invading pathogens. Among the TLR family, TLR5 is the only that senses and recognizes flagellin, the major protein of bacterial flagella. TLR5 has been reported to be under overall purifying selection in mammals, with a small proportion of codons under positive selection. However, the variation of substitution rates among major mammalian groups has been neglected. Here, we… 
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