Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity.

@article{McMartin1987AnalysisOS,
  title={Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity.},
  author={Colin McMartin and L E Hutchinson and Russell Hyde and Garry Peters},
  journal={Journal of pharmaceutical sciences},
  year={1987},
  volume={76 7},
  pages={535-40}
}
An octapeptide and a protein, of molecular weights 800 and 34,000, respectively, were found to have nasal bioavailabilities of 73 and 0.6%, respectively, in the rat. This data, combined with reported values for 23 other compounds, indicated good availability without adjuvants for all molecules up to 1000 molecular weight (mean 70%, SD between compounds 26… CONTINUE READING