Analysis of spliceosomal proteins in Trypanosomatids reveals novel functions in mRNA processing.

@article{Tkacz2010AnalysisOS,
  title={Analysis of spliceosomal proteins in Trypanosomatids reveals novel functions in mRNA processing.},
  author={Itai Dov Tkacz and Sachin Kumar Gupta and Vadim Volkov and Mali Romano and Tomer Haham and Pawel Tulinski and Ilana Lebenthal and Shulamit Michaeli},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 36},
  pages={27982-99}
}
In trypanosomatids, all mRNAs are processed via trans-splicing, although cis-splicing also occurs. In trans-splicing, a common small exon, the spliced leader (SL), which is derived from a small SL RNA species, is added to all mRNAs. Sm and Lsm proteins are core proteins that bind to U snRNAs and are essential for both these splicing processes. In this study, SmD3- and Lsm3-associated complexes were purified to homogeneity from Leishmania tarentolae. The purified complexes were analyzed by mass… CONTINUE READING

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  • J. H. Lee, T. N. Nguyen, B. Schimanski, A. Günzl
  • Eukaryot. Cell 6,
  • 2007

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