Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.

@article{Salomone2008AnalysisOS,
  title={Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.},
  author={Salvatore Salomone and E Michelle Potts and Sarah Tyndall and Peter Ching-Tze Ip and Jerold Chun and V Brinkmann and Christian Waeber},
  journal={British journal of pharmacology},
  year={2008},
  volume={153 1},
  pages={140-7}
}
BACKGROUND AND PURPOSE Sphingosine 1-phosphate (S1P) selectively and potently constricts isolated cerebral arteries, but this response has not been pharmacologically characterized. EXPERIMENTAL APPROACH The receptor subtype(s) involved in S1P-induced cerebrovascular constriction were characterized using genetic (S1P(2) and S1P(3) receptor null mice) and pharmacological tools (phospho-FTY720, a S1P(1/3/4/5) receptor agonist; SEW2871, a S1P(1) receptor agonist, JTE-013, a S1P(2) receptor… CONTINUE READING
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