Analysis of solvent residues in pharmaceutical bulk drugs by wall-coated open tubular gas chromatography.

@article{Foust1989AnalysisOS,
  title={Analysis of solvent residues in pharmaceutical bulk drugs by wall-coated open tubular gas chromatography.},
  author={Don Foust and M S Bergren},
  journal={Journal of chromatography},
  year={1989},
  volume={469},
  pages={
          161-73
        }
}
A simple general method for the determination of solvent residues in drugs is described. The procedure is based on wide-bore wall coated open tubular (WCOT) gas chromatographic analysis of bulk drug solutions. The use of wide-bore WCOT columns with chemically crosslinked methyl silicone stationary phases offers improvements in specificity and sensitivity over earlier packed-column methods. The factors that influence method accuracy are discussed, including a consideration of instrumental and… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.