Analysis of skeletal muscle metabolome: evaluation of extraction methods for targeted metabolite quantification using liquid chromatography tandem mass spectrometry.

@article{Rammouz2010AnalysisOS,
  title={Analysis of skeletal muscle metabolome: evaluation of extraction methods for targeted metabolite quantification using liquid chromatography tandem mass spectrometry.},
  author={Rabih El Rammouz and Fabien L{\'e}tisse and St{\'e}phanie H. Durand and Jean-Charles Portais and Ziad Wadih Moussa and Xavier Fern{\'a}ndez},
  journal={Analytical biochemistry},
  year={2010},
  volume={398 2},
  pages={169-77}
}
Functional metabolomics of skeletal muscle involves the simultaneous identification and quantification of a large number of metabolites. For this purpose, the extraction of metabolites from animal tissues is a crucial technical step that needs to be optimized. In this work, five extraction methods for skeletal muscle metabolome analysis using liquid chromatography tandem mass spectrometry (LC-MS/MS) were tested. Bird skeletal muscles sampled postmortem and quenched in liquid nitrogen were used… CONTINUE READING

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