Analysis of single nucleotide polymorphisms in the 5'-flanking region of tumor necrosis factor-alpha gene in Japanese patients with early-onset periodontitis.

@article{Endo2001AnalysisOS,
  title={Analysis of single nucleotide polymorphisms in the 5'-flanking region of tumor necrosis factor-alpha gene in Japanese patients with early-onset periodontitis.},
  author={Morito Endo and Hideaki Tai and Koichi Tabeta and Tetsuo Kobayashi and Kazuhisa Yamazaki and Hiromasa Yoshie},
  journal={Journal of periodontology},
  year={2001},
  volume={72 11},
  pages={1554-9}
}
BACKGROUND Early-onset periodontitis (EOP) is considered to have a genetic basis, which has not been clearly defined. The tumor necrosis factor-alpha (TNF-alpha) gene polymorphism as one of the genetic factors may influence the expression of several chronic inflammatory diseases. The aim of the present study was to evaluate whether the polymorphisms in the 5'-flanking region of the TNF-alpha gene are associated with Japanese EOP patients. METHODS Forty-six Japanese, generalized EOP (G-EOP… CONTINUE READING

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