Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas

@inproceedings{Bonzheim2008AnalysisOS,
  title={Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas},
  author={Irina Bonzheim and E Geissinger and Wen-Yu Chuang and Sabine Roth and Philipp Stroebel and Alexander Marx and Peter Reimer and M. Wilhelm and Bernhard Puppe and Andreas Rosenwald and Hans-Konrad Mueller-Hermelink and Thomas Ruediger},
  booktitle={Journal of hematopathology},
  year={2008}
}
Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these… CONTINUE READING