Analysis of single-molecule FRET trajectories using hidden Markov modeling.

@article{McKinney2006AnalysisOS,
  title={Analysis of single-molecule FRET trajectories using hidden Markov modeling.},
  author={Sean A. McKinney and Chirlmin Joo and Taekjip Ha},
  journal={Biophysical journal},
  year={2006},
  volume={91 5},
  pages={1941-51}
}
The analysis of single-molecule fluorescence resonance energy transfer (FRET) trajectories has become one of significant biophysical interest. In deducing the transition rates between various states of a system for time-binned data, researchers have relied on simple, but often arbitrary methods of extracting rates from FRET trajectories. Although these methods have proven satisfactory in cases of well-separated, low-noise, two- or three-state systems, they become less reliable when applied to a… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 24 references

Extreme conformational diversity in human telomeric DNA.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 2 Excerpts

Observing spontaneous branch migration of Holliday junctions one step at a time.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 3 Excerpts

Single-molecule enzymology of RNA: essential functional groups impact catalysis from a distance.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 2 Excerpts

What is a hidden Markov model?

Nature Biotechnology • 2004
View 1 Excerpt

A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 3 Excerpts

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