Analysis of sibutramine metabolites as N-trifluoroacetamide and O-trimethylsilyl derivatives by gas chromatography-mass spectrometry in urine.

@article{Sardela2009AnalysisOS,
  title={Analysis of sibutramine metabolites as N-trifluoroacetamide and O-trimethylsilyl derivatives by gas chromatography-mass spectrometry in urine.},
  author={V F Sardela and Maria Rosa Motta and Monica Costa Padilha and Henrique Marcelo Gualberto Pereira and Francisco Radler de Aquino Neto},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2009},
  volume={877 27},
  pages={3003-11}
}
A method for identifying the metabolites of sibutramine 1-(4(chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl))cyclobutanemethanamine) in urine, utilizing a double derivatization strategy, with N-methyl-N-(trimethylsilyl)-trifluoroacetamide and N-methyl-bis-(trifluoroacetamide), in gas chromatography/mass spectrometry is proposed. This methodology results… CONTINUE READING