Analysis of shared heritability in common disorders of the brain

@article{Anttila2018AnalysisOS,
  title={Analysis of shared heritability in common disorders of the brain},
  author={Verneri Anttila and Brendan K. Bulik-Sullivan and Hilary K. Finucane and Raymond K. Walters and Jose T Bras and Laramie E. Duncan and Valentina Escott-Price and Guido J. Falcone and Padhraig Gormley and Rainer Malik and Nikolaos A. Patsopoulos and Stephan Ripke and Zhi Wei and Dongmei Yu and Phil H. Lee and Patrick Turley and Benjamin Grenier‐Boley and Vincent Chouraki and Yoichiro Kamatani and Claudine Berr and Luc Letenneur and Didier Hannequin and Philippe Amouyel and Anne Boland and Jean-François Deleuze and Emmanuelle Duron and Badri N. Vardarajan and Christiane Reitz and Alison M. Goate and Matthew J. Huentelman and M. Ilyas Kamboh and Eric B. Larson and Ekaterina Rogaeva and Peter H St George-Hyslop and Hakon Hakonarson and Walter A Kukull and Lindsay A. Farrer and Lisa L. Barnes and Thomas G. Beach and Fatma Yesim Demirci and Elizabeth Head and Christine M. Hulette and Gregory A. Jicha and John S. K. Kauwe and Jeffrey A. Kaye and James B. Leverenz and Allan I. Levey and Andrew P. Lieberman and Vernon S Pankratz and Wayne W. Poon and Joseph F. Quinn and Andrew J. Saykin and Lon S Schneider and Amanda G. Smith and J.A. Sonnen and Robert A. Stern and Vivianna M. Van Deerlin and Linda J Van Eldik and Denise H. Harold and Giancarlo Russo and David C. Rubinsztein and Anthony J. Bayer and Magda Tsolaki and Petra Proitsi and Nick C Fox and Harald Hampel and Michael J. Owen and Simon Mead and Peter Passmore and Kevin Morgan and Markus M. N{\"o}then and Martin N. Rossor and Michelle K Lupton and Per Hoffmann and Johannes Kornhuber and Brian A Lawlor and Andrew McQuillin and Ammar Al-Chalabi and Joshua C Bis and A. Ruiz and Merc{\`e} Boada and Sudha Seshadri and Alexa S. Beiser and Kenneth M. Rice and Sven J. van der Lee and Philip L. De Jager and Daniel H. Geschwind and Matthias Riemenschneider and Steffi G. Riedel-Heller and Jerome I. Rotter and Gerhard Ransmayr and Bradley T. Hyman and Carlos Cruchaga and Montserrat Alegret and Bendik Slagsvold Winsvold and Priit Palta and Kai-How Farh and Ester Cuenca-Le{\'o}n and Nicholas A. Furlotte and Tobias Kurth and Lannie Ligthart and Gisela M. Terwindt and Tobias M. Freilinger and Caroline Ran and Scott D. Gordon and Guntram Borck and Hieab H. H. Adams and Terho Lehtim{\"a}ki and Juho Wedenoja and Julie E. Buring and Markus Sch{\"u}rks and Maria Gudlaug Hrafnsdottir and Jouke- Jan Hottenga and Brenda W.J.H. Penninx and Ville Artto and Mari Anneli Kaunisto and Salli Veps{\"a}l{\"a}inen and Nicholas G. Martin and Grant W. Montgomery and Mitja I. Kurki and Eija H{\"a}m{\"a}l{\"a}inen and Hailiang Huang and Jie Huang and Cynthia Sandor and Caleb Webber and Bertram Muller-Myhsok and Stefan Schreiber and Veikko V Salomaa and Elizabeth A Loehrer and Hartmut G{\"o}bel and Alfons Macaya and Patricia Pozo‐Rosich and Thomas Hansen and Thomas M. Werge and Jaakko Kaprio and Andres Metspalu and Christian Kubisch and Michel D. Ferrari and Andrea Carmine Belin and Arn M.J.M. van den Maagdenberg and John-Anker Zwart and Dorret I. Boomsma and Nicholas Eriksson and Jes Olesen and Daniel I. Chasman and Dale R. Nyholt and Andreja Avbersek and Larry Baum and Samuel F. Berkovic and Jonathan P. Bradfield and Russell J. Buono and Claudia B. Catarino and Patrick Cossette and Peter de Jonghe and Chantal Depondt and Dennis J. Dlugos and Thomas N Ferraro and Jacqueline A. French and Helle Hjalgrim and Jenny Jamnadas-Khoda and Reetta K{\"a}lvi{\"a}inen and Wolfram S. Kunz and Holger Lerche and Costin Leu and Dick Lindhout and Warren D. Lo and Daniel H. Lowenstein and Mark McCormack and Rikke Steensbjerre M{\o}ller and Anne M. Molloy and Ping Wing Ng and Karen L. Oliver and Michael D Privitera and Rodney A. Radtke and Ann-Kathrin Ruppert and Thomas Sander and Steven C. Schachter and Christoph J. Schankin and Ingrid Eileen Scheffer and Susanne Schoch and Sanjay M. Sisodiya and Philip E. M. Smith and Michael R. Sperling and Pasquale Striano and Rainer Surges and G Neil Thomas and Frank Visscher and Christopher D. Whelan and Federico Zara and Erin L. Heinzen and Anthony G. Marson and Felicitas Becker and Hans Stroink and Fritz Zimprich and Thomas Gasser and Raphael J. Gibbs and Peter Heutink and Maria Martinez and Huw R Morris and Manu Sharma and Mina Ryten and Kin Y. Mok and Sara L. Pulit and Steve Bevan and Elizabeth G Holliday and John Richard Attia and Thomas W.K. Battey and Giorgio B. Boncoraglio and Vincent N. Thijs and Wei-Min Chen and Braxton D. Mitchell and Peter M. Rothwell and Pankaj Sharma and Cathie L. M. Sudlow and Astrid Moura Vicente and Hugh S. Markus and Christina E. Kourkoulis and Joana Pera and Miriam R. Raffeld and Scott L. Silliman and Vesna Boraska Perica and Laura M. Thornton and Laura M. Huckins and Nigel William Rayner and Cathryn M. Lewis and M{\'o}nica Gratac{\'o}s and Filip Rybakowski and Anna Keski-Rahkonen and Anu Raevuori and James I Hudson and Ted Reichborn-Kjennerud and Palmiero Monteleone and Andreas Karwautz and Katrin Mannik and Jessica H Baker and Julie K O'toole and Sara E. Trace and Oliver S. P. Davis and Sietske G. Helder and Stefan Ehrlich and Beate Herpertz-Dahlmann and Unna N Danner and Annemarie A van Elburg and Maurizio Clementi and Monica Forzan and Elisa Docampo and Jolanta Lissowska and Joanna Hauser and Alfonso Tortorella and Mario Maj and Fragiskos Gonidakis and Konstantinos Tziouvas and Hana Papezov{\'a} and Zeynep Yilmaz and Gudrun Wagner and Sarah Cohen-woods and Stefan Herms and Antonio Juli{\`a} and Raquel Rabionet and Danielle M. Dick and Samuli Ripatti and Ole Andreas Andreassen and Thomas Espeseth and Astri Johansen Lundervold and Vidar M. Steen and Dalila Pinto and Stephen W. Scherer and Harald N. Aschauer and Alexandra Schosser and Lars Alfredsson and Leonid Padyukov and Katherine A Halmi and James Mitchell and Michael A. Strober and Andrew W. Bergen and Walter H. Kaye and Jin P. Szatkiewicz and Bru Cormand and Josep Antoni Ramos-Quiroga and Cristina S{\'a}nchez-Mora and Marta Ribas{\'e}s and Miguel Casas and Amaia Herv{\'a}s and Maria J. Arranz and Jan Haavik and Tetyana Zayats and Stefan Johansson and Nigel Melvillle Williams and Astrid Dempfle and Aribert Rothenberger and Jonna Kuntsi and Robert D. Oades and Tobias Banaschewski and Barbara Franke and Jan K. Buitelaar and Alejandro Arias Vasquez and Alysa E. Doyle and Andreas Reif and Klaus-Peter Lesch and Christine M. Freitag and Olga Rivero and Haukur P{\'a}lmason and Marcel Romanos and Kate Langley and Marcella Rietschel and Stephanie H. Witt and Soeren Dalsgaard and Anders Dupont B{\o}rglum and Irwin D. Waldman and Beth Wilmot and Nikolas Molly and Claiton H.D. Bau and Jennifer Crosbie and Russell J. Schachar and Sandra K. Loo and James J. McGough and Eug{\^e}nio Hor{\'a}cio Grevet and Sarah E. Medland and Elise B Robinson and Lauren A. Weiss and Elena Bacchelli and Anthony J. Bailey and Vanessa H Bal and Agatino Battaglia and Catalina Betancur and Patrick F. Bolton and Rita M. Cantor and Patr{\'i}cia B. S. Celestino-Soper and Geraldine Dawson and Silvia De Rubeis and Frederico Duque and Andrew J. Green and Sabine M Klauck and Marion Leboyer and Pat Levitt and Elena Maestrini and Shrikant M. Mane and Daniel Moreno- De-Luca and Jeremy R Parr and Regina Regan and Abraham Reichenberg and Sven Sandin and Jacob A. S. Vorstman and Thomas H. Wassink and Ellen M. Wijsman and Edwin H. Cook and Susan L Santangelo and Richard Delorme and Bernadette Rog{\'e} and Tiago R. Magalh{\~a}es and Dan E. Arking and Thomas G. Schulze and Robert C. Thompson and Jana Strohmaier and Keith Matthews and Ingrid Melle and Derek W. Morris and Douglas H.R. Blackwood and Andrew M. McIntosh and Sarah L Bergen and Martin Schalling and Stéphane Jamain and Anna Maaser and Sascha B. Fischer and C{\'e}line S. Reinbold and Janice M. Fullerton and Jos{\'e} Guzm{\'a}n-Parra and Ferm{\'i}n Mayoral and Peter R. Schofield and Sven Cichon and Thomas W. M{\"u}hleisen and Franziska Degenhardt and Johannes Schumacher and Michael Bauer and Philip B. Mitchell and Elliot S. Gershon and John R. Rice and James B. Potash and Peter P. Zandi and Nick Craddock and I. Nicol Ferrier and M. Alda and Guy A. Rouleau and Gustavo Turecki and Roel A. Ophoff and Carlos N. Pato and Adebayo Anjorin and Eli A. Stahl and Markus Leber and Piotr M. Czerski and Cristiana Cruceanu and Ian R Jones and Danielle Posthuma and Till F. M. Andlauer and Andreas J. Forstner and Fabian Streit and Bernhard T. Baune and Tracy Air and Grant C. B. Sinnamon and Naomi R. Wray and Donald J. Macintyre and David J. Porteous and Georg Homuth and Margarita Rivera and Jakob Grove and Christel M. Middeldorp and Ian B. Hickie and Michele L. Pergadia and Divya Mehta and Johannes H. Smit and Rick Jansen and Eco J. C. de Geus and Erin C. Dunn and Qingqin S. Li and Matthias Nauck and Robert A. Schoevers and Aartjan T.F. Beekman and James A. Knowles and Alexander Viktorin and Paul D. Arnold and Cathy L. Barr and Gabriel Bedoya-Berr{\'i}o and O Joseph Bienvenu and Helena Paula Brentani and Christie L. Burton and Beatriz Camarena and Carolina Cappi and Danielle C. Cath and Maria Cristina Cavallini and Daniele Cusi and Sabrina Michelle Darrow and Damiaan Denys and Eske M. Derks and Andrea Dietrich and Thomas V. Fernandez and Martijn Figee and Nelson B. Freimer and Gloria Gerber and Marco A Grados and Erica Greenberg and Gregory L. Hanna and Andreas Hartmann and Matthew E Hirschtritt and Pieter J. Hoekstra and Alden Yen-Wen Huang and Chaim Huyser and Cornelia L Illmann and Michael A. Jenike and Samuel Kuperman and Bennett L. Leventhal and C. Lochner and Gholson J. Lyon and Fabio Macciardi and Marcos Madruga-Garrido and Irene A. Malaty and Athanasios Maras and Lauren M. McGrath and Eur{\'i}pedes Constantino Miguel and Pablo Mir and Gerald Nestadt and Humberto Nicolini and Michael S. Okun and Andrew J. Pakstis and Peristera Paschou and John Piacentini and Christopher Pittenger and Kerstin Jessica Plessen and Vasily Ramensky and Eliana Marisa Ramos and Victor I. Reus and Margaret Anne Richter and Mark A. Riddle and Mary May Robertson and Veit Roessner and Maria Conceiç{\~a}o do Ros{\'a}rio and Jack Samuels and Paul Sandor and Dan J Stein and Fotis Tsetsos and Filip van Nieuwerburgh and Sarah L. Weatherall and Jens R. Wendland and Tomasz Wolańczyk and Yulia Worbe and Gwyneth C. Zai and Fernando S. Goes and Nicole C.R. McLaughlin and Paul S. Nestadt and Hans J{\"o}rgen Grabe and Christel Depienne and Anuar Konkashbaev and Nuria Lanzagorta and Ana Victoria Valencia-Duarte and Elvira Bramon and Nancy G. Buccola and Wiepke Cahn and Murray J. Cairns and Siow Ann Chong and David Cohen and Benedicto Crespo-Facorro},
  journal={Science},
  year={2018},
  volume={360}
}
Brainstorming diseases Consistent classification of neuropsychiatric diseases is problematic because it can lead to misunderstanding of etiology. The Brainstorm Consortium examined multiple genome-wide association studies drawn from more than 200,000 patients for 25 brain-associated disorders and 17 phenotypes. Broadly, it appears that psychiatric and neurologic disorders share relatively little common genetic risk. However, different and independent pathways can result in similar clinical… Expand
A structural brain network of genetic vulnerability to psychiatric illness
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Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
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The results show substantial similarities in sMRI phenotypes among neuropsychiatric disorders and suggest that these similarities are accounted for, in part, by corresponding similarities in common genetic variant architectures. Expand
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The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology
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This Review summarizes the evidence for a polygenic architecture of schizophrenia that involves a large number of risk alleles across the whole range of population frequencies and suggests a substantial overlap between schizophrenia and psychiatric, behavioural and cognitive traits, which could influence future disease classifications and mechanistic research. Expand
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It is suggested that common genetic variants underlying the risk of anxiety disorders contribute to elevated risks of MDD, SCZ, ADHD and neuroticism and reduced quality of life, putamen volume and cognitive performance. Expand
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