Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring


PURPOSE: We present a case-control study of seven polymorphisms of six genes involved in homocysteine/folate pathway as risk factors for Down syndrome. Gene-gene/allele-allele interactions, haplotype analysis and the association with age at conception were also evaluated.METHODS: We investigated 94 Down syndrome-mothers and 264 control-women from Campania… (More)
DOI: 10.1097/01.gim.0000228206.21793.82


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