Analysis of sertraline (Zoloft) and its major metabolite in postmortem specimens by gas and liquid chromatography.

Abstract

We report methods for the analysis of sertraline and desmethylsertraline in postmortem biological fluids. The extraction method is based on a widely used procedure employing n-butyl chloride, and instrumental analysis is performed using GC/MS and HPLC with photodiode array detection. We report retention index, mass spectral, and UV-vis properties of the… (More)

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