Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis.

@article{Szewczuk2008AnalysisOS,
  title={Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis.},
  author={Lawrence M. Szewczuk and Mary Katherine Tarrant and V. Alaric Sample and William J. Drury and Jin Zhang and Philip A Cole},
  journal={Biochemistry},
  year={2008},
  volume={47 39},
  pages={10407-19}
}
Serotonin N-acetyltransferase [arylalkylamine N-acetyltransferase (AANAT)] is a key circadian rhythm enzyme that drives the nocturnal production of melatonin in the pineal. Prior studies have suggested that its light and diurnal regulation involves phosphorylation on key AANAT Ser and Thr residues which results in 14-3-3zeta recruitment and changes in catalytic activity and protein stability. Here we use protein semisynthesis by expressed protein ligation to systematically explore the effects… CONTINUE READING
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