Analysis of segregation and aneuploidy in two reciprocal translocation carriers, t(3;9)(q26.2;q32) and t(3;9)(p25;q32), by triple-color fluorescence in situ hybridization

@article{Honda1999AnalysisOS,
  title={Analysis of segregation and aneuploidy in two reciprocal translocation carriers, t(3;9)(q26.2;q32) and t(3;9)(p25;q32), by triple-color fluorescence in situ hybridization},
  author={Hiroshi Honda and Norio Miharu and Yoshiyuki Ohashi and Nao Honda and Toshiro Hara and Koso Ohama},
  journal={Human Genetics},
  year={1999},
  volume={105},
  pages={428-436}
}
Meiotic segregation patterns of chromosomes 3 and 9 were analyzed in sperm of two translocation carriers (t(3;9)(q26.2;q32) and t(3;9)(p25;q32)) by triple-color fluorescent in situ hybridization (FISH) with a telomeric DNA probe in addition to two centromeric probes. The frequencies of each sperm product resulting from alternate or adjacent I, adjacent II and 3:1 segregation in a t(3;9)(q26.2;q32) translocation carrier were 88.35%, 5.44% and 5.94%, respectively. On the other hand, the… CONTINUE READING

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Detec - tion of structural abnormalities in spermatozoa of a translocation carrier t ( 3 ; 11 ) ( q 27 . 3 ; q 24 . 3 ) by triple FISH

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