Analysis of results of toxicological examinations performed by coroners' or medical examiners' laboratories in 2000 drug-involved deaths in nine major U. S. cities.

  title={Analysis of results of toxicological examinations performed by coroners' or medical examiners' laboratories in 2000 drug-involved deaths in nine major U. S. cities.},
  author={E. C. Dinovo and Louis A. Gottschalk and Frederick L. Mcguire and Herman Birch and Jon Heiser},
  journal={Clinical chemistry},
  volume={22 6},
Data were collected on 2000 deaths in which psychoactive drugs were involved. The data were submitted by medical examiners or coroners in nine U. S. cities from their case files. The 2000 cases comprise a representative sample from each of these cities of deaths from psychoactive drugs between 1972 through 1974. This report details inter-city differences in methods and practices of the toxicological examination as well as the type and numbers of drugs reported. Even when the same analytical… 
A review of psychoactive drug-involved deaths in nine major United States cities.
National programs of drug abuse deterrence or prevention and treatment should deal specifically with the variety of psychoactive drug-involved deaths occurring in different urban areas rather than approaching these problems globally as if they were uniform and homogeneous.
Drug levels in fatal cases where death was not directly attributable to drug toxicity
The postmortem levels of commonly encountered substances in the West of Scotland are looked at, where on the basis of information made available, it was clear that the presence of a drug and/or drugs had not contributed to the death of that individual.
Forensic Toxicology Proficiency Monitoring: Results, Experiences, and Comments
The major findings of the surveys were that the toxicological laboratories associated wlth the medical examiners' or coroners' offices show significant interlaboratory and intralaboratory variations In identification and quanlitation of drugs.
A Collection of Therapeutic, Toxic and Fatal Blood Drug Concentrations in Man
A compilation of therapeutic, toxic and fatal blood concentration ranges of 298 drugs of interest to clinical pharmacologists, clinical toxicologists, and forensic toxicologists is provided.
Drug abuse deaths in nine cities: a survey report.
The characteristics of the decedents, the system of data collection, and the activities involved in certifying a death are looked at; these kinds of data have never before been collected in depth on as comprehensive a sample of cases.
Poisoning due to psychotropic drugs.
This review will examine the clinical features and management of poisoning due to psychotropic agents used by Hollister (1978), which indicates a 50% fall in the mortality from barbiturate poisoning over the same period.
Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics
The data provided are useful for the therapeutic monitoring of pharmacotherapies, to facilitate the diagnostic assessment and monitoring of acute and chronic intoxications as well as to support forensic and clinical expert opinions.
Fatal poisonings attributed to benzodiazepines in Britain during the 1980s.
Benzodiazepines are indeed much less toxic than the barbiturates they superseded, but they are not innocuous and temazepam in particular requires further evaluation.
Relation of postmortem blood alcohol and drug concentrations in fatal poisonings involving amitriptyline, propoxyphene and promazine
Alcohol concentration proved to be a more sensitive indicator of alcohol-drug interaction than drug concentration, suggesting that when alcohol is present, relatively small overdoses of the studied drugs may result in fatal poisoning.
Acute overdosage with benzodiazepine derivatives
Ingestion of benzodiazepines together with other drugs appears to be considerably more common than Benzodiazepine overdosage alone as a cause of intoxication, and the severity of intoxication in such cases of multiple drug ingestion probably depends largely on the type and quantity of nonbenzodiazep drugs taken.


Drug levels in cases of poisoning.
The present review is an attempt to compile the data on the toxic levels of drugs which are commonly encountered in toxicological analysis.
Results of a nine-laboratory survey of forensic toxicology proficiency.
Toxicological determinations are crucial to coroners' or medical examiners' judgments that drugs are significantly involved in a death. However, differences in laboratory procedures, thoroughness of
Therapeutic and toxic concentrations of more than 100 toxicologically significant drugs in blood, plasma, or serum: a tabulation.
Human blood, plasma, or serum concentrations of drugs important to the analytical toxicologist are tabulated, as an aid to interpretation of analytical toxicological results. Significant
Regional psychosocial and biomedical differences in psychoactive drug-involved deaths in the United States
  • In preparation,
  • 1976
HSM-42-72-139 for the period
  • HSM-42-72-139 for the period
  • 1973
The Investigation and Reporting of Drug-Involved Deaths
  • National Institute on Drug Abuse. Report on NIDA Contract No. HSM-42-72-139 for the period June
  • 1973
The Development of a Uniform System for Reporting and Recording Drug-Related Deaths, vols
  • I and II. U. S. Dept. of HEW, National Institute of Mental Health. Report on NIMH Contract No. HSM-42-72-139 for the period June
  • 1972
The Development of a Uniform System for Reporting and Recording Drug-Related Deaths, vols. I and II
  • The Development of a Uniform System for Reporting and Recording Drug-Related Deaths, vols. I and II
The In- vestigation and Reporting of Drug-Involved Deaths
  • U. S. Dept. of HEW, Alcohol, Drug Abuse, and Mental Health Administration