Analysis of regulatory protease sequences identified through bioinformatic data mining of the Schistosoma mansoni genome
@article{Bos2009AnalysisOR, title={Analysis of regulatory protease sequences identified through bioinformatic data mining of the Schistosoma mansoni genome}, author={D. H. Bos and Chris Mayfield and D. Minchella}, journal={BMC Genomics}, year={2009}, volume={10}, pages={488 - 488} }
BackgroundNew chemotherapeutic agents against Schistosoma mansoni, an etiological agent of human schistosomiasis, are a priority due to the emerging drug resistance and the inability of current drug treatments to prevent reinfection. Proteases have been under scrutiny as targets of immunological or chemotherapeutic anti-Schistosoma agents because of their vital role in many stages of the parasitic life cycle. Function has been established for only a handful of identified S. mansoni proteases… CONTINUE READING
26 Citations
Evolutionary histories of expanded peptidase families in Schistosoma mansoni.
- Medicine, Biology
- Memorias do Instituto Oswaldo Cruz
- 2011
- 10
- Highly Influenced
- PDF
Genome-wide analysis of regulatory proteases sequences identified through bioinformatics data mining in Taenia solium
- Biology, Medicine
- BMC Genomics
- 2013
- 9
- Highly Influenced
Annotation of virulence factors in schistosomes for the development of a SchistoVir database
- Biology
- 2013
- 2
- PDF
Expression Profile of the Schistosoma japonicum Degradome Reveals Differential Protease Expression Patterns and Potential Anti-schistosomal Intervention Targets
- Biology, Computer Science
- PLoS Comput. Biol.
- 2014
- 20
- PDF
Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.
- Biology, Medicine
- Biochimie
- 2016
- 21
Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity
- Biology, Medicine
- PloS one
- 2014
- 43
- PDF
Comparative genomic analysis of aspartic proteases in eight parasitic platyhelminths: insights into functions and evolution.
- Biology, Medicine
- Gene
- 2015
- 3
Gene Atlasing of Digestive and Reproductive Tissues in Schistosoma mansoni
- Biology, Medicine
- PLoS neglected tropical diseases
- 2011
- 63
- PDF
Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development
- Biology, Medicine
- Front. Immunol.
- 2015
- 25
- PDF
References
SHOWING 1-10 OF 83 REFERENCES
New Perspectives on Host-Parasite Interplay by Comparative Transcriptomic and Proteomic Analyses of Schistosoma japonicum
- Biology, Medicine
- PLoS pathogens
- 2006
- 226
- PDF
Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni
- Biology, Medicine
- Nature Genetics
- 2003
- 447
- PDF
Identification of Novel Proteases and Immunomodulators in the Secretions of Schistosome Cercariae That Facilitate Host Entry *S
- Biology, Medicine
- Molecular & Cellular Proteomics
- 2006
- 179
- PDF
Schistosome transcriptomes: new insights into the parasite and schistosomiasis.
- Biology, Medicine
- Trends in molecular medicine
- 2004
- 77
Schistosomiasis Mansoni: Novel Chemotherapy Using a Cysteine Protease Inhibitor
- Biology, Medicine
- PLoS medicine
- 2007
- 231
- PDF
Proteinases and associated genes of parasitic helminths.
- Biology, Medicine
- Advances in parasitology
- 1999
- 277
RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade.
- Biology, Medicine
- Molecular and biochemical parasitology
- 2008
- 111
Schistosome Invasion of Human Skin and Degradation of Dermal Elastin Are Mediated by a Single Serine Protease*
- Biology, Medicine
- The Journal of Biological Chemistry
- 2000
- 95
- PDF