Analysis of rapamycin induced autophagy in Dictyostelium discoideum.

@article{Swer2014AnalysisOR,
  title={Analysis of rapamycin induced autophagy in Dictyostelium discoideum.},
  author={Pynskhem Bok Swer and Rakhee Lohia and Shweta Saran},
  journal={Indian journal of experimental biology},
  year={2014},
  volume={52 4},
  pages={
          295-304
        }
}
Natural autophagy and autophagic cell death is being studied in the model system, D. discoideum, which has well known genetic and experimental advantages over the other known systems. There is no apoptotic machinery present in this organism which could interfere with the non-apoptotic cell death. The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway which when inhibited by the drug rapamycin induces autophagy. Rapamycin was originally discovered as an anti-fungal agent but… CONTINUE READING

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