Analysis of pulegone and its enanthiomeric distribution in mint-flavoured food products

  title={Analysis of pulegone and its enanthiomeric distribution in mint-flavoured food products},
  author={Francesco Siano and Maurizio Catalfamo and Domenico Cautela and Luigi Servillo and Domenico Castaldo},
  journal={Food Additives \& Contaminants},
  pages={197 - 203}
A procedure for the extraction and determination of pulegone enanthiomers in mint essential oils and mint products (syrups, dried leaves, toothpaste, lozenges, candy and chewing-gum) was developed. The compounds were recovered from the food matrices by employing a simultaneous distillation–extraction (SDE) technique with a Likens–Nickerson apparatus using dichloromethane as an extraction solvent. The analyses were performed by capillary gas chromatography mass spectrometry (GC/MS). Experiments… 
Salting-out assisted liquid-liquid extraction method coupled to gas chromatography for the simultaneous determination of thujones and pulegone in beverages
ABSTRACT A fast, simple and sensitive salting-out assisted liquid-liquid extraction method for the simultaneous determination of thujones and pulegone in beverage samples was developed. The
Volatile Oils of Nepeta tenuifolia (Jing Jie) as an Alternative Medicine against Multidrug-Resistant Pathogenic Microbes
  • Yi-Hsuan Lee, Chao-Min Wang, K. Tung
  • Biology
    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
  • 2018
The antibacterial activity of EOs against both Pseudomonas aeruginosa reference strains and clinical isolates was relatively lower than other Gram-negative pathogens, and the fragmentation pathways of pulegone and its derivatives by LC-ESI-MS/MS are proposed in this study.
Essential Oil Composition of Aerial Parts of Salvia mirzayanii Rech. f. & Esfand. from Southern Fars, Iran
Abstract The chemical composition of the essential oils from aerial parts of Salvia mirzayanii Rech. f. & Esfand. growing endemic in southern Iran were extracted using hydrodistillation method and
A comparative study of the analysis of human urine headspace using gas chromatography–mass spectrometry
A comparative analysis of unfrozen and frozen-thawed urine showed that samples retained the same number of compounds although variations in the peak areas for some compounds were observed.
Larvicidal evaluation of the Origanum majorana L. Essential Oil against the larvae of the Aedes aegypti mosquito
Essential oil did not present antioxidant activity, but it has high cytotoxic activity against A. salina, which was resistant at all concentrations.
Evaluation of larvicidal potential against larvae of Aedes aegypti (Linnaeus, 1762) and of the antimicrobial activity of essential oil obtained from the leaves of Origanum majorana L.
Essential oil did not present antioxidant activity, but it has high cytotoxic activity against A. aegypti L. aureus, which was resistant at all concentrations.
Hepatotoxicity of monoterpenes and sesquiterpenes
The present review is focused on the hepatotoxic properties of monoterpenes and sesquiterpenes, plant secondary metabolites that represent the major components of essential oils wildly used in folk medicines, pharmaceutical industry and cosmetics.
Monoterpenes: Essential Oil Components with Valuable Features.
This review provides comprehensive information on chemical structures and classification of monoterpenes, describes their biosynthesis pathways and introduces plant families and species rich in noteworthy monoterpene.


Hepatotoxicity and pulmonary toxicity of pennyroyal oil and its constituent terpenes in the mouse.
Chiral compounds of essential oils XIV: Simultaneous stereoanalysis of buchu leaf oil compounds†
Multidimensional enantioselective gas chromatography, employing heart-cutting from a non-chiral precolumn onto a selectivity adjusted, modified cyclodextrin coated chiral main column, permits the
The metabolism of the abortifacient terpene, (R)-(+)-pulegone, to a proximate toxin, menthofuran.
Investigation with (R)-(+)-pulegone-d6 and 18O2 strongly indicate that menthofuran is formed by a sequence of reactions that involve: 1) oxidation of an allylic methyl group, 2) intramolecular cyclization to form a hemiketal, and 3) dehydration to form the furan.
Short term toxicity study in rats dosed with pulegone and menthol.
Metabolic disposition of a monoterpene ketone, piperitenone, in rats: evidence for the formation of a known toxin, p-cresol.
A probable mechanism for the formation of p-cresol from piperitenone (I) via the intermediacy of metabolite III has been proposed.
Biochemical, histopathological and ultrastructural changes in rat liver induced by r‐( + )‐pulegone, a monoterpene ketone
The time course profile of the hepatocytes after treatment with pulegone indicates that endoplasmic reticulum is the organelle most affected, following which other degenerative changes occur ultimately leading to cell death.
The genuineness of two mint essential oils