Analysis of protein interactions in situ by proximity ligation assays.

@article{Koos2013AnalysisOP,
  title={Analysis of protein interactions in situ by proximity ligation assays.},
  author={Bj{\"o}rn Koos and Linda K Andersson and Carl-Magnus Clausson and Karin Grannas and Axel Klaesson and Ga{\"e}lle Cane and Ola S{\"o}derberg},
  journal={Current topics in microbiology and immunology},
  year={2013},
  volume={377},
  pages={
          111-26
        }
}
The fate of the cell is governed by interactions among proteins, nucleic acids, and other biomolecules. It is vital to look at these interactions in a cellular environment if we want to increase our understanding of cellular processes. Herein we will describe how the in situ proximity ligation assay (in situ PLA) can be used to visualize protein interactions in fixed cells and tissues. In situ PLA is a novel technique that uses DNA, together with DNA modifying processes such as ligation… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS

Inhibition of Karyopherin-α2 Augments Radiation-Induced Cell Death by Perturbing BRCA1-Mediated DNA Repair

  • International journal of molecular sciences
  • 2019
VIEW 4 EXCERPTS
CITES METHODS
HIGHLY INFLUENCED

Fundamentals of protein interaction network mapping

  • Molecular systems biology
  • 2015
VIEW 3 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Similar Papers

Loading similar papers…