Analysis of proinflammatory and anti-inflammatory cytokine serum concentrations in patients with multiple sclerosis by using a multiplexed immunoassay.

@article{Martins2011AnalysisOP,
  title={Analysis of proinflammatory and anti-inflammatory cytokine serum concentrations in patients with multiple sclerosis by using a multiplexed immunoassay.},
  author={Thomas Bernd Martins and John W. Rose and Troy D. Jaskowski and Andrew R. Wilson and Dee Husebye and Hanieh S Seraj and Harry Raymond Hill},
  journal={American journal of clinical pathology},
  year={2011},
  volume={136 5},
  pages={696-704}
}
We examined cytokines and other inflammatory markers in serum samples from 833 patients with multiple sclerosis and 117 healthy control subjects. A multiplexed immunoassay was used to assess the concentrations of 13 cytokines/inflammatory markers: interferon (IFN)-γ; interleukins (ILs)-1β, 2, 4, 5, 6, 8, 10, 12, and 13; tumor necrosis factor (TNF)-α; IL-2 receptor; and soluble CD40 ligand. Significant increases between patients and control subjects were found for IFN-γ (mean, 7.5 vs 0.4 pg/mL… CONTINUE READING
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