Analysis of primate genomic variation reveals a repeat-driven expansion of the human genome.

@article{Liu2003AnalysisOP,
  title={Analysis of primate genomic variation reveals a repeat-driven expansion of the human genome.},
  author={Ge Liu and Shaying Zhao and Jeffrey A. Bailey and S{\"u}leyman Cenk Sahinalp and Can Alkan and Eray Tuzun and Eric D. Green and Evan E. Eichler},
  journal={Genome research},
  year={2003},
  volume={13 3},
  pages={358-68}
}
We performed a detailed analysis of both single-nucleotide and large insertion/deletion events based on large-scale comparison of 10.6 Mb of genomic sequence from lemur, baboon, and chimpanzee to human. Using a human genomic reference, optimal global alignments were constructed from large (>50-kb) genomic sequence clones. These alignments were examined for the pattern, frequency, and nature of mutational events. Whereas rates of single-nucleotide substitution remain relatively constant (1-2 x… CONTINUE READING
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A comparison of whole - genome shotgun - derived mouse chromosome 16 and the human genome

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