Analysis of pre- and postsynaptic factors of the serotonin system in rabbit retina

  title={Analysis of pre- and postsynaptic factors of the serotonin system in rabbit retina},
  author={Cheryl K. Mitchell and Dianna A. Redburn},
  journal={The Journal of Cell Biology},
  pages={64 - 73}
[3H]Serotonin is accumulated by a specific set of amacrine cells in the rabbit retina. These cells also accumulate the neurotoxin, 5,7-dihydroxytryptamine, and show signs of necrosis within 4 h of in vivo exposure to the drug. Biochemical analysis of [3H]serotonin uptake reveal a sodium- and temperature-dependent, high affinity uptake system with a Km of 0.94 microM and Vmax of 1.08 pmol/mg protein/min. [3H]Tryptophan is also accumulated in rabbit retinal homogenates by a high affinity process… CONTINUE READING
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