Analysis of polysorbate 80 and its related compounds by RP-HPLC with ELSD and MS detection.

@article{Zhang2012AnalysisOP,
  title={Analysis of polysorbate 80 and its related compounds by RP-HPLC with ELSD and MS detection.},
  author={Ruixuan Zhang and Yongren Wang and Liquan Tan and Hai Yan Zhang and Mary Qu Yang},
  journal={Journal of chromatographic science},
  year={2012},
  volume={50 7},
  pages={
          598-607
        }
}
The chemical composition of polysorbate 80 strongly influences the physicochemical properties and performance of many products. Consequently, a reliable characterization of polysorbate 80 is crucial for many applications. However, the exact composition of these chemical mixtures cannot be determined by colorimetry, hydrolysis, size-exclusion chromatography, nuclear magnetic resonance or mass spectrometry (MS). Meanwhile, due to the strong retention of higher esters on the reversed-phase (RP… CONTINUE READING

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Alkaline hydrolysis to increase the selectivity of colorimetric determination of polysorbate.

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  • 2017

Fatty acid composition analysis in polysorbate 80 with high performance liquid chromatography coupled to charged aerosol detection.

  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2015

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