Analysis of polymorphisms in the olfactory G-protein Golf in major depression

  title={Analysis of polymorphisms in the olfactory G-protein Golf in major depression},
  author={Peter Zill and Rolf R. Engel and Thomas C. Baghai and Peter Zwanzger and Cornelius Sch{\"u}le and Christo Minov and Stefanie Behrens and Rainer Rupprecht and Hans-J{\"u}rgen M{\"o}ller and Brigitta Bondy},
  journal={Psychiatric Genetics},
It is well established that G-proteins represent essential regulatory components in transmembrane signaling. The α subunit of the olfactory G-protein Golf (GNAL) maps to a region on chromosome 18 where linkage to affective disorders has been reported, as well as a parent-of-origin effect in affective disorders with some markers near the locus for the α subunit of the Golf gene. We investigated whether two polymorphisms in the α subunit of the Golf gene (A→G in intron 3, and T→G in intron 10… 

Investigation of the G protein subunit Galphaolf gene (GNAL) in attention deficit/hyperactivity disorder.

Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder

The results of this study suggest that polymorphisms in the human NAPG gene may represent risk factors for the development of bipolar disorder, but before such a role can be established, the results must be confirmed in additional populations of bipolar Disorder patients and controls.

Mood disorders and their treatment: alterations in the regulation of receptor‐G protein coupling

It is to be hoped that an admixture of genomics, proteomics, multi‐marker, large‐scale automated measures, together with the “old” biochemical approaches, will enable the development of an objective biological differential diagnostic system for major mental disorders that will also enable monitoring and predicting response to treatments.

Heterotrimeric g proteins: insights into the neurobiology of mood disorders.

A compilation of the most relevant research topics about the implication of heterotrimeric G proteins in the etiology of mood disorders will provide a broad perspective of this potential therapeutic target field.

Alternative transcripts and evidence of imprinting of GNAL on 18p11.2

The identification of a transcriptional variant of the GNAL gene in this region, employing an alternative first exon that is 5′ to the originally identified start site, suggests that GNAL, and possibly other genes in the region, is subject to epigenetic regulation and strengthens the case for a susceptibility gene inThis region.

Molecular studies of major depressive disorder: the epigenetic perspective

Epigenetic factors – inherited and acquired modifications of DNA and histones that regulate various genomic functions occurring without a change in nuclear DNA sequence – offer new insights about many of the non-Mendelian features of major depression, and provide a direct mechanistic route via which the environment can interact with the genome.

Application of G-proteins in the molecular diagnosis of psychiatric disorders

The accumulated data supports the potential use of G-protein measures as state-dependent markers for the biochemical diagnosis of mental disorders and as aid in the biochemical monitoring of the response to a specific treatment.

Transcriptome Sequencing of Gene Expression in the Brain of the HIV-1 Transgenic Rat

The findings of abnormal gene expression patterns in HIV-1Tg rats suggest mechanisms underlying the deficits in learning and memory and vulnerability to drug addiction and other psychiatric disorders observed in HIV -positive patients.

Identification of a Specific Assembly of the G Protein Golf as a Critical and Regulated Module of Dopamine and Adenosine-Activated cAMP Pathways in the Striatum

In the principal neurons of striatum (medium spiny neurons, MSNs), cAMP pathway is primarily activated through the stimulation of dopamine D1 and adenosine A2A receptors, these receptors being mainly



No association between chromosome-18 markers and lithiumresponsive affective disorders

Human Golf gene polymorphisms and vulnerability to bipolar disorder

Two intronic polymorphisms of the human alpha subunit of the olfactory G‐protein (Golf) are described and a purine is substituted for a pyrimidine in the ‘polypyrimidine’ tract of the 3′ splice site, a single base substitution of the type which has been associated with aberrant splicing in the androgen receptor gene.

No association between chromosome-18 markers and lithium-responsive affective disorders.

An allelic association study of excellent responders to lithium was conducted with a candidate gene (Golf, a G-protein receptor gene) and five other chromosome-18p markers and the data do not support the hypothesis that the tested loci confer a major susceptibility for affective disorders.

G proteins: implications for psychiatry.

  • H. Manji
  • Biology
    The American journal of psychiatry
  • 1992
The author reviews the literature dealing with G protein coupling to second messenger generation, the role of G protein in regulating both the convergence and divergence of neurotransmitter action in the CNS, and the involvement of G proteins in a variety of clinical conditions, with an emphasis on psychiatric conditions and their treatments.

Association study on the DUSP6 gene, an affective disorder candidate gene on 12q23, performed by using fluorescence resonance energy transfer-based melting curve analysis on the LightCycler

This study demonstrates that melting curve analysis on the LightCycler is an accurate, rapid and robust method for discriminating genotypes from biallelic markers and has the potential for use in high throughput scanning for and genotypes of single nucleotide polymorphisms (SNPs).

Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis.

The results suggest the existence, on chromosome 18p, of a potential susceptibility locus for functional psychoses, and the existence of association/linkage disequilibrium in the presence of linkage.

The Genes for Major Psychosis: Aberrant Sequence or Regulation?

  • A. Petronis
  • Psychology, Biology
  • 2000

Sequence and genomic organization of the human G-protein Golfα gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia

The sequence and genomic organization of the human Golfα (GNAL) gene were determined and knowledge of the sequence and structure provides essential information for further analysis of the GNAL locus at chromosome 18p11 which has been linked to bipolar disorder and schizophrenia.

Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families

Evidence for linkage of bipolar affective disorder to DNA markers on chromosome 18 was reexamined in a large sample of German bipolar families and the findings on 18p11.2 and 18q22–23 support prior evidence for susceptibility loci in these regions.

CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia

In this review, evidence from both basic science and clinical research implicating disturbances in postreceptor signal transduction in the pathophysiology and pharmacotherapy of AD and SCZ is evaluated.