Analysis of polymorphisms in the &agr;‐subunit of the olfactory G‐protein Golf in lithium‐treated bipolar patients

  title={Analysis of polymorphisms in the \&agr;‐subunit of the olfactory G‐protein Golf in lithium‐treated bipolar patients},
  author={Peter Zill and Petros N Malitas and Brigitta Bondy and Rolf R. Engel and Fotini Boufidou and Stefanie Behrens and Basil Alevizos and Chryssoula Nikolaou and George N. Christodoulou},
  journal={Psychiatric Genetics},
Objective This study examines the &agr;‐subunit of the olfactory G‐protein (Golf) as a possible candidate gene for bipolar disorder. The &agr;‐subunit of the Golf gene maps to a region on chromosome 18p that has been implicated in several linkage studies as a potential site of a bipolar disorder susceptibility loci. Methods We investigated whether two polymorphisms in the &agr;‐subunit of the Golf gene (A→G in intron 3 and T→G in intron 10) are associated with bipolar disorder in a sample of… 

Association analysis of CHMP1.5 genetic variation and bipolar disorder

Variation in the CHMP1.5 gene within intron 5 of G-olf does not appear to be associated with bipolar disorder and a systematic assessment of genetic variation in the region using association studies will be necessary.

Investigation of the G protein subunit Galphaolf gene (GNAL) in attention deficit/hyperactivity disorder.

Analysis of GNAL Polymorphisms in Attention Deficit Hyperactivity Disorder

The presence of the allele A in rs8095592 could be preventive from ADHD in those with family history, and was significantly more common in the patients who had a family history of ADHD.

The Genetics of Response to and Side Effects of Lithium Treatment in Bipolar Disorder: Future Research Perspectives

The mechanisms of action of lithium are delineated, the results of genetic research on lithium response and side effects are summarized, and the need for larger sample sizes and “multi-omics” approaches is apparent.

Pharmacogenetics in mood disorder

Genes encoding target receptors and signal transduction systems may predict the efficacy of drug therapy in mood disorders and additional predictors of treatment response in bipolar disorder may include the immediate early genes, mitochondrial genes and epigenetic mechanisms.

Molecular genetics of bipolar disorder

An overview of linkage studies of BPD is given, concluding that the regions with the best evidence for linkage include areas on chromosomes 2p, 4p,4q, 6q, 8q, 11p, 12q, 13q, 16p, 16q, 18p, 18q, 21q, 22q and Xq.

Pharmacogenetic considerations in the treatment of psychiatric disorders

Although current data are too sparse to allow the development of guidelines for using pharmacogenetic testing in routine clinical practice, the field of psychiatric pharmacogenetics is rapidly developing and identification of genetic biomarkers that predict therapeutic response and risk of side effects will ultimately help the practitioner to choose effective and safe treatment for patients suffering from psychiatric disorders.

Genomic imprinting in the development and evolution of psychotic spectrum conditions

  • B. Crespi
  • Psychology, Biology
    Biological reviews of the Cambridge Philosophical Society
  • 2008
An important role for imprinted genes in the etiologies of psychotic and autistic spectrum conditions is consistent with neurodevelopmental models of these disorders, and with predictions from the conflict theory of genomic imprinting.

The Human Obesity Gene Map: The 2005 Update

The 12th update of the human obesity gene map is presented, which incorporates published results up to the end of October 2005, and shows putative loci on all chromosomes except Y.



No association between chromosome-18 markers and lithiumresponsive affective disorders

No association between chromosome-18 markers and lithium-responsive affective disorders.

An allelic association study of excellent responders to lithium was conducted with a candidate gene (Golf, a G-protein receptor gene) and five other chromosome-18p markers and the data do not support the hypothesis that the tested loci confer a major susceptibility for affective disorders.

Human Golf gene polymorphisms and vulnerability to bipolar disorder

Two intronic polymorphisms of the human alpha subunit of the olfactory G‐protein (Golf) are described and a purine is substituted for a pyrimidine in the ‘polypyrimidine’ tract of the 3′ splice site, a single base substitution of the type which has been associated with aberrant splicing in the androgen receptor gene.

Association study on the DUSP6 gene, an affective disorder candidate gene on 12q23, performed by using fluorescence resonance energy transfer-based melting curve analysis on the LightCycler

This study demonstrates that melting curve analysis on the LightCycler is an accurate, rapid and robust method for discriminating genotypes from biallelic markers and has the potential for use in high throughput scanning for and genotypes of single nucleotide polymorphisms (SNPs).

Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis.

The results suggest the existence, on chromosome 18p, of a potential susceptibility locus for functional psychoses, and the existence of association/linkage disequilibrium in the presence of linkage.

The Genes for Major Psychosis: Aberrant Sequence or Regulation?

  • A. Petronis
  • Psychology, Biology
  • 2000

Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families

Evidence for linkage of bipolar affective disorder to DNA markers on chromosome 18 was reexamined in a large sample of German bipolar families and the findings on 18p11.2 and 18q22–23 support prior evidence for susceptibility loci in these regions.

Investigation of the candidate genes ACTHR and Golf for bipolar illness by the transmission/disequilibrium test

Several versions of the transmission/disequilibrium test (TDT) were applied to the two candidate genes ACTHR and Golf for bipolar illness and evidence for linkage and association was found for ACTHR for paternal transmission in support of a parent‐of‐origin effect.

Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.

Results imply a susceptibility gene in the pericentromeric region of chromosome 18, with a complex mode of inheritance, and two plausible candidate genes, a corticotropin receptor and the alpha subunit of a GTP binding protein, have been localized to this region.

Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect.

The results provide further support for linkage of BPAD to chromosome 18 and the first molecular evidence for a parent-of-origin effect operating in this disorder.