Analysis of platelet glycoprotein Ia (alpha2 integrin) allele frequencies in three North American populations reveals genetic association between nucleotide 807C/T and amino acid 505 Glu/Lys (HPA-5) dimorphisms.

@article{Reiner1998AnalysisOP,
  title={Analysis of platelet glycoprotein Ia (alpha2 integrin) allele frequencies in three North American populations reveals genetic association between nucleotide 807C/T and amino acid 505 Glu/Lys (HPA-5) dimorphisms.},
  author={A. Reiner and K. M. Aramaki and G. Teramura and L. Gaur},
  journal={Thrombosis and haemostasis},
  year={1998},
  volume={80 3},
  pages={
          449-56
        }
}
Glycoprotein Ia (alpha2 integrin) is a subunit of the heterodimeric membrane complex (GPIa/IIa) that mediates platelet adhesion to collagen. Several nucleotide sequence variations of GPIa have been described. A nucleotide 1648 G/A dimorphism that leads to a Glu/Lys substitution at amino acid 505 is responsible for the human platelet antigen system, HPA-5. Recently, two other linked GPIa nucleotide dimorphisms involving codons Phe224 and Thr246 were identified: a C/T substitution at nucleotide… Expand
The GPIa C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction
Platelet glycoprotein gene polymorphisms and risk of thrombosis: facts and fancies.
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